Multiple Choice QuestionsMatch the following tumor cell origin with their nomenclature.
| Tumor cell Origin | Nomenclature |
| (a) Muscle cell | (i) Carcinoma |
| (b) Germ Cell | (ii) Sarcoma |
| (c) Epithelial Cell | (iii) Leukemia |
| (d) White blood | (iv) Teratocarcinoma |
| (a) | (b) | (c) | (d) |
| (i) | (iii) | (iv) | (ii) |
| (a) | (b) | (c) | (d) |
| (iv) | (i) | (ii) | (iii) |
| (a) | (b) | (c) | (d) |
| (iii) | (i) | (iv) | (i) |
| (a) | (b) | (c) | (d) |
| (ii) | (iv) | (i) | (iii) |
Many cytotoxic T lymphocytes intiate killing of target cells via delivery of molecules that could induce target-cell damage directly. Which one of the following is the most appropriate?
Interferon γ
Peroxynitrite
Lysozyme
Granzyme
D.
Granzyme
Granzymes are serine proteases released by cytoplasmic granuels within cytotoixc T cells and natural killer (NK) cells. They induce programmed cell death (apoptosis) in the target cell, thus eliminating cells that have become cancerous or are infected with viruses or bacteria. Granzymes also kill bacteria and inhibit viral replication. In NK cells and T cells, granzymes are packaged in cytotoxic granuels with perforin. Granzymes can also be detected in the rough endoplasmic reticulum, golgi complex, and the trans-golgi reticulum.
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